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November 13, 2024

Prolong Pharmaceuticals to Present Clinical Data regarding PP-007, PEGylated carboxyhemoglobin bovine product, at the 2024 International Symposium on Blood Substitutes (ISBS)

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October 30, 2024

U.S. Food and Drug Administration (FDA) Grants Prolong Pharmaceuticals FDA Fast Track Designation for Novel Stroke Therapy (PP-007) in HEMERA-1 Clinical Study

Positive HEMERA-1 data pave the way for further neuroprotection trials during ‘thrombectomy era’

HEMERA‐1 CarboxyHEMoglobin OxygEn Delivery for Evascularization in Acute Stroke: A Prospective, Randomized Phase 1 Clinical Trial

October 1, 2023

Measuring And Controlling Potency Of A Targetless Biologic: Study Of Pegylated Hemoglobin

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October 1, 2022

Purification and Heat Inactivation of an Oxidation Prone Protein: Study of Hemoglobin

October 1, 2020

Characterization of large conjugate (PEGylated) biologics: Combination approach with CE-SDS and SEC-MALS methods

October 1, 2020

Application of Slope Spectroscopy® to the Measurement of Co-oximetry Parameters in Bovine Hemoglobin: The Case of Measuring Low Concentration Met Hemoglobin in Bovine Hemoglobin Samples

Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis.

Resuscitation with PEGylated carboxyhemoglobin preserves renal cortical oxygenation and improves skeletal muscle microcirculatory flow during endotoxemia

Targeting the HO-1/CO Pathway with Sanguinate: Toward Development of a Novel Anti-inflammatory Therapy for Cystic Fibrosis (CF) Lung Disease

Microvascular and Systemic Impact of Resuscitation with PEGylated Carboxyhemoglobin-Based Oxygen Carrier or Hetastarch in a Rat Model of Transient Hemorrhagic Shock.

Alternatives to Transfusion: A Case Report and Brief History of Artificial Oxygen Carriers

Artificial Blood: The History and Current Perspectives of Blood Substitutes

REVIEW

April 1, 2017

41(4): 346-350. Abuchowski A.

SANGUINATE (PEGylated Carboxyhemoglobin Bovine): Mechanism of Action and Clinical Update. Artif Organs.

SCD

March 1, 2017

39(1):20-27 | Misra H, Bainbridge J, Berryman J, Abuchowski A, Galvez KM, Uribe LF, Hernandez AL, Sosa NR.

A Phase Ib open label, randomized, safety study of SANGUINATE® in patients with sickle cell anemia. Rev Bras Hematol Hemoter.

BNAO

February 1, 2017

29: 73-80 | Thenuwara K, Thomas J, Ibsen M, Ituk U, Choi K, Nickel E, Goodheart MJ.

Use of hyperbaric oxygen therapy and PEGylated carboxyhemoglobin bovine in a Jehovah's Witness with life-threatening anemia following postpartum hemorrhage. Int J Obstet Anesth.

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